A probabilistic model for the extraction of expression levels from oligonucleotide arrays.
نویسندگان
چکیده
In this work we present a probabilistic model to estimate summaries of Affymetrix GeneChip probe level data. Comparisons with two different models were made both on a publicly available dataset and on a study performed in our laboratory, showing that our model performs better for consistency of fold change.
منابع مشابه
10 A Probabilistic Model for the Extraction of Expression Levels from Oligonucleotide Arrays
Oligonucleotide expression array technology has been adopted in many areas of biomedical research to measure simultaneously the level of messenger ribonucleic acid (mRNA) transcipts for thousands of genes. Affymetrix GeneChip arrays are the most popular amongst them. In this technology each gene is represented by a set of 11 to 20 pairs of oligonu-cleotides that we refer to as probes. Each prob...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 31 Pt 6 شماره
صفحات -
تاریخ انتشار 2003